Vemurafenib Induces Senescent Phenotype with Increased Adhesion in BRAF Mutant A375 but not in Wild Type BRAF SK-MEL-2 Melanoma Cells

Vemurafenib Induces Senescent Phenotype with Increased Adhesion in BRAF Mutant A375 but not in Wild Type BRAF SK-MEL-2 Melanoma Cells

Purpose: The present study aimed to determine the selective effects of BRAF V600E inhibitor on focal adhesion in melanoma cells with respect to their phenotypic reprogramming. Methods: Flow cytometry was used to analyse the distribution of BRAFV600E and BRAFWT melanoma cells throughout the cell cycl...

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Bibliographic Details
Main Authors: Aleksandra Rashidovna Esimbekova, Vasiliy Dmitrievich Belenyuk, Andrey Anatolievich Savchenko, Tatiana Gennadievna Ruksha
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2025-04-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
melanoma
vemurafenib
focal adhesion
senescence
cell cycle
g0 phase
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-15-176.pdf
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https://apb.tbzmed.ac.ir/PDF/apb-15-176.pdf

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