Evidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional studyResearch in context

Evidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional studyResearch in context

Summary: Background: Synuclein pathology in neurodegenerative diseases, such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB), begins years before motor or cognitive symptoms arise. Alpha-Synuclein seed amplification assays (α-syn SAA) may detect aggregated synuclein before symptoms...

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Main Authors: Kenneth Marek, David S. Russell, Luis Concha-Marambio, Seung Ho Choi, Danna Jennings, Michael C. Brumm, Christopher S. Coffey, Ethan Brown, John Seibyl, Matthew Stern, Claudio Soto, Andrew Siderowf
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:EBioMedicine
Subjects:
Parkinson’s disease
Biomarkers
Dopamine transporter imaging
Prodromal
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000118
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http://www.sciencedirect.com/science/article/pii/S2352396425000118

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