Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure
Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF). We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/293863 |
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| author | Lia Millucci Lorenzo Ghezzi Giulia Bernardini Daniela Braconi Piero Tanganelli Annalisa Santucci |
| author_facet | Lia Millucci Lorenzo Ghezzi Giulia Bernardini Daniela Braconi Piero Tanganelli Annalisa Santucci |
| author_sort | Lia Millucci |
| collection | DOAJ |
| description | Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF). We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients distinguished in idiopathic dilated cardiomyopathy (DC) affected and hypertrophic Cardiomyopathy (HC) affected, endorsing the presumptive association of early CHF with IAA. We utilized a multiple method, using Congo red (CR) staining, CR fluorescence (CRF), and immunohistochemistry to assess the presence of IAA in CHF. Immunostaining showed a moderate deposition of IAA in the atrium surrounding working myocardium with small intracellular deposits. Our findings suggest a monitoring of young CHF cases for the development of IAA. Our study also demonstrated how the concurrent use of immunohistochemistry, CR, and CRF may greatly enhance the detection of low-grade amyloid deposits. |
| format | Article |
| id | doaj-art-d6c8f3f187bd4ab7ac952377330d0b07 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d6c8f3f187bd4ab7ac952377330d0b072025-02-03T01:02:07ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/293863293863Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart FailureLia Millucci0Lorenzo Ghezzi1Giulia Bernardini2Daniela Braconi3Piero Tanganelli4Annalisa Santucci5Dipartimento di Biotecnologie, Università degli Studi di Siena, Via Fiorentina 1, 53100 Siena, ItalyDipartimento di Biotecnologie, Università degli Studi di Siena, Via Fiorentina 1, 53100 Siena, ItalyDipartimento di Biotecnologie, Università degli Studi di Siena, Via Fiorentina 1, 53100 Siena, ItalyDipartimento di Biotecnologie, Università degli Studi di Siena, Via Fiorentina 1, 53100 Siena, ItalyDepartimento di Patologia Umana e Oncologia, Università degli Studi di Siena, 53100 Siena, ItalyDipartimento di Biotecnologie, Università degli Studi di Siena, Via Fiorentina 1, 53100 Siena, ItalyAtrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF). We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients distinguished in idiopathic dilated cardiomyopathy (DC) affected and hypertrophic Cardiomyopathy (HC) affected, endorsing the presumptive association of early CHF with IAA. We utilized a multiple method, using Congo red (CR) staining, CR fluorescence (CRF), and immunohistochemistry to assess the presence of IAA in CHF. Immunostaining showed a moderate deposition of IAA in the atrium surrounding working myocardium with small intracellular deposits. Our findings suggest a monitoring of young CHF cases for the development of IAA. Our study also demonstrated how the concurrent use of immunohistochemistry, CR, and CRF may greatly enhance the detection of low-grade amyloid deposits.http://dx.doi.org/10.1100/2012/293863 |
| spellingShingle | Lia Millucci Lorenzo Ghezzi Giulia Bernardini Daniela Braconi Piero Tanganelli Annalisa Santucci Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure The Scientific World Journal |
| title | Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure |
| title_full | Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure |
| title_fullStr | Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure |
| title_full_unstemmed | Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure |
| title_short | Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure |
| title_sort | prevalence of isolated atrial amyloidosis in young patients affected by congestive heart failure |
| url | http://dx.doi.org/10.1100/2012/293863 |
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