Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model

Abstract Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders characterized by immune cell infiltration of muscle tissue accompanied by inflammation. Treatment of IIMs is challenging, with few effective therapeutic options due to the lack of appropriate models that successfu...

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Main Authors: Akiko Nishidate, Kana Takemoto, Yuki Imura, Mikako Murase, Ryu Yamanaka, Manami Kikuchi, Junpei Anan, Sayuka Kato, Airi Akatsuka, Sachiko Mochizuki, Yuzo Koda
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Inflammation and Regeneration
Subjects:
Myositis
Polymyositis
Humanized mice
CD8+ T cells
Online Access:https://doi.org/10.1186/s41232-025-00365-6
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https://doi.org/10.1186/s41232-025-00365-6

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