A versatile drug delivery system targeting senescent cells

A versatile drug delivery system targeting senescent cells

Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a drug delivery system based on the enc...

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Main Authors: Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Format: Article
Language:English
Published: Springer Nature 2018-07-01
Series:EMBO Molecular Medicine
Subjects:
chemotherapy
fibrosis
nanomedicine
palbociclib
senescence
Online Access:https://doi.org/10.15252/emmm.201809355
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https://doi.org/10.15252/emmm.201809355

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