H<sub>2</sub>S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins

H<sub>2</sub>S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins

Endogenously produced hydrogen sulfide (H<sub>2</sub>S) is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H<sub>2</sub>S levels have proven cardioprotective in models of acute myocardial infarction (MI) and heart failure (HF). The present...

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Bibliographic Details
Main Authors: Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
H<sub>2</sub>S
SG-1002
oxidative stress
reactive oxygen species (ROS)
cardiovascular diseases
gasotransmitters
Online Access:https://www.mdpi.com/2227-9059/11/2/612
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