Exploring the disconnect: mechanisms underpinning the absence of physical function improvement with SGLT2 inhibitors

Current evidence suggests sodium-glucose cotransporter 2 inhibitors (SGLT2i) do not consistently improve patient physical function, despite improvements in clinical symptoms and reductions in both adiposity and body weight. We highlight heterogenous methodologies in SGLT2i physical function trials....

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Bibliographic Details
Main Authors: Cian Sutcliffe, Jack A. Sargeant, Thomas Yates, Melanie J. Davies, Luke A. Baker
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Systems Biology
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Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2025.1593229/full
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