Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation

Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation

Abstract Chimeric antigen receptor (CAR) T cell therapy constituted a recent breakthrough in the treatment of poor prognosis cancers by harnessing therapeutic T cells with an engineered non-MHC restricted antigen recognition transgene. CAR constructs are expressed in addition to endogenous T cell re...

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Main Authors: Pablo Gonzalez-Garcia, Noelia Moares, Isabel Serrano-García, Ricardo Fernandez-Cisnal, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Wenjie Yi-He, Juan P. Muñoz-Miranda, Antonio Gabucio, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptors (CAR)
Signaling
Immune Synapsis
Costimulation
Phosphorylation
Solid tumor
Online Access:https://doi.org/10.1186/s12967-025-06857-w
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https://doi.org/10.1186/s12967-025-06857-w

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