Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice

Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice

Abstract STX12 (syntaxin12 or syntaxin13), a member of the SNARE protein family, plays a crucial role in intracellular vesicle transport and membrane fusion. Our previous research demonstrated that Stx12 knockout mice exhibit perinatal lethality with iron deficiency anemia. Despite its importance, t...

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Main Authors: Dan-Hua Liu, Fang Li, Run-Zhou Yang, Zhuanbin Wu, Xiao-Yan Meng, Sen-Miao Li, Wen-Xiu Li, Jia-Kang Li, Dian-Dian Wang, Rui-Yu Wang, Shu-Ang Li, Pei-Pei Liu, Jian-Sheng Kang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
cGAS-STING
Inflammation
Mitochondria
mtDNA release
STX12
Online Access:https://doi.org/10.1186/s12964-025-02141-y
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https://doi.org/10.1186/s12964-025-02141-y

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