Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate-altitude exposure and identified the potentiality of beta-alanine to ameliorate hyperuricemia

Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate-altitude exposure and identified the potentiality of beta-alanine to ameliorate hyperuricemia

Background: High-altitude exposure has been associated with an increased risk of hyperuricemia (HU) and gout, though the underlying mechanisms remain poorly understood. Methods: We conducted a comprehensive analysis of the serum metabolome and phenome in both discovery and validation cohorts of Han...

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Main Authors: Xuanfu Chen, Guoxiang Zou, Zhibo Yang, Xin Qi, Feier Song, Long Peng, Dingchen Wang, Jingyan Zhou, Jiahui Ma, Haiwei He, Yimei Hong, Yu-E Wang, Yanqun Fan, Zhipeng Liu, Xin Li
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Moderate altitude
Asymptomatic hyperuricemia
Urate
Serum metabolome
Risk prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500059X
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