Associations between sleep traits and colorectal cancer: a mendelian randomization analysis
BackgroundAlthough many researches have shown a relationship between sleeping habits and the risk of developing colorectal cancer (CRC), there is a lack of data from randomized controlled trials (RCTs) to support this point. Hence, this study used Mendelian randomization (MR) to robustly assess whet...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1416243/full |
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| author | Xiangyue Meng Enshuo Fan Dan Lv Yongjing Yang Shixin Liu |
| author_facet | Xiangyue Meng Enshuo Fan Dan Lv Yongjing Yang Shixin Liu |
| author_sort | Xiangyue Meng |
| collection | DOAJ |
| description | BackgroundAlthough many researches have shown a relationship between sleeping habits and the risk of developing colorectal cancer (CRC), there is a lack of data from randomized controlled trials (RCTs) to support this point. Hence, this study used Mendelian randomization (MR) to robustly assess whether five primary sleep characteristics are directly linked with the risk of CRC occurrence.MethodsIn the performed study, the main Mendelian randomization analysis was conducted using approaches such as Inverse Variance Weighting (IVW), MR Egger, and weighted median method. To this end, five genetically independent variants associated with the sleep-related characteristics (chronotype, sleep duration, insomnia, daytime napping, and daytime fatigue) were identified and used as instrumental variables. Publicly accessible GWAS (Genome-Wide Association Study) data were used to identify these variants to investigate the putative causal relationships between sleep traits and CRC. Additionally, we conducted sensitivity analyses to minimize possible biases and verify the consistency of our results.ResultsMendelian randomization analyses showed that an morning chronotype reduces the risk of CRC with the IVW method, hence, odds ratio (OR) of 1.21 and 95% confidence interval (CI) of 0.67-0.93, which is statistically significant at P = 5.74E-03. Conversely, no significant evidence was found to suggest that sleep duration, insomnia, daytime napping, or daytime sleepiness have a direct causal impact on CRC risk according to the IVW analysis.ConclusionsFindings from our Mendelian randomization analyses suggest that an individual’s chronotype may contribute to an increased risk of CRC. It is advisable for individuals to adjust their sleep patterns as a preventative measure against CRC. |
| format | Article |
| id | doaj-art-d595acf35f23488baca142677aa58bd3 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-d595acf35f23488baca142677aa58bd32025-02-06T05:21:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14162431416243Associations between sleep traits and colorectal cancer: a mendelian randomization analysisXiangyue Meng0Enshuo Fan1Dan Lv2Yongjing Yang3Shixin Liu4Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Radiotherapy, Jilin Cancer Hospital, Changchun, ChinaDepartment of Radiotherapy, Jilin Cancer Hospital, Changchun, ChinaBackgroundAlthough many researches have shown a relationship between sleeping habits and the risk of developing colorectal cancer (CRC), there is a lack of data from randomized controlled trials (RCTs) to support this point. Hence, this study used Mendelian randomization (MR) to robustly assess whether five primary sleep characteristics are directly linked with the risk of CRC occurrence.MethodsIn the performed study, the main Mendelian randomization analysis was conducted using approaches such as Inverse Variance Weighting (IVW), MR Egger, and weighted median method. To this end, five genetically independent variants associated with the sleep-related characteristics (chronotype, sleep duration, insomnia, daytime napping, and daytime fatigue) were identified and used as instrumental variables. Publicly accessible GWAS (Genome-Wide Association Study) data were used to identify these variants to investigate the putative causal relationships between sleep traits and CRC. Additionally, we conducted sensitivity analyses to minimize possible biases and verify the consistency of our results.ResultsMendelian randomization analyses showed that an morning chronotype reduces the risk of CRC with the IVW method, hence, odds ratio (OR) of 1.21 and 95% confidence interval (CI) of 0.67-0.93, which is statistically significant at P = 5.74E-03. Conversely, no significant evidence was found to suggest that sleep duration, insomnia, daytime napping, or daytime sleepiness have a direct causal impact on CRC risk according to the IVW analysis.ConclusionsFindings from our Mendelian randomization analyses suggest that an individual’s chronotype may contribute to an increased risk of CRC. It is advisable for individuals to adjust their sleep patterns as a preventative measure against CRC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1416243/fullcolorectal cancerchronotypesleep durationinsomniadaytime sleepinessdaytime napping |
| spellingShingle | Xiangyue Meng Enshuo Fan Dan Lv Yongjing Yang Shixin Liu Associations between sleep traits and colorectal cancer: a mendelian randomization analysis Frontiers in Oncology colorectal cancer chronotype sleep duration insomnia daytime sleepiness daytime napping |
| title | Associations between sleep traits and colorectal cancer: a mendelian randomization analysis |
| title_full | Associations between sleep traits and colorectal cancer: a mendelian randomization analysis |
| title_fullStr | Associations between sleep traits and colorectal cancer: a mendelian randomization analysis |
| title_full_unstemmed | Associations between sleep traits and colorectal cancer: a mendelian randomization analysis |
| title_short | Associations between sleep traits and colorectal cancer: a mendelian randomization analysis |
| title_sort | associations between sleep traits and colorectal cancer a mendelian randomization analysis |
| topic | colorectal cancer chronotype sleep duration insomnia daytime sleepiness daytime napping |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1416243/full |
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