Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1

Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1

Introduction: Gut microbes and their metabolites play crucial roles in the pathogenesis of diabetic kidney disease (DKD). However, which one and how specific gut-derived metabolites affect the progression of DKD remain largely unknown. Objectives: This study aimed to investigate the potential roles...

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Main Authors: Yan Zeng, Man Guo, Qi Wu, Xiaozhen Tan, Chunxia Jiang, Fangyuan Teng, Jiao Chen, Fanjie Zhang, Xiumei Ma, Xinyue Li, Junling Gu, Wei Huang, Chunxiang Zhang, Betty Yuen-Kwan Law, Yang Long, Yong Xu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
Indole-3-propionic acid
SIRT1
Oxidative stress
Mitochondria
Diabetic kidney disease
Glomerular endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003618
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