Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature
Clindamycin is a bacteriostatic lincosamide antibiotic with a broad spectrum. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. The incidence is unknown. It is characterized by increases in aspartate and alanine transaminases. There may be no sympt...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2016/2724738 |
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| author | Jerome Okudo Nwabundo Anusim |
| author_facet | Jerome Okudo Nwabundo Anusim |
| author_sort | Jerome Okudo |
| collection | DOAJ |
| description | Clindamycin is a bacteriostatic lincosamide antibiotic with a broad spectrum. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. The incidence is unknown. It is characterized by increases in aspartate and alanine transaminases. There may be no symptoms and the treatment is to stop the administration of clindamycin. We have described a 62-year-old African American female medicated with acetaminophen and clindamycin who had initially presented to the dental clinic for the evaluation of gum pain following tooth extraction. She had significantly increased levels of liver transaminases, which trended downwards on quitting the medication. |
| format | Article |
| id | doaj-art-d58978da6c4d490cb28e003e559c712f |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-d58978da6c4d490cb28e003e559c712f2025-02-03T05:58:59ZengWileyCase Reports in Hepatology2090-65872090-65952016-01-01201610.1155/2016/27247382724738Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the LiteratureJerome Okudo0Nwabundo Anusim1School of Public Health, University of Texas, 1200 Pressler Street, Houston, TX 77030, USADepartment of Medicine, Saint Joseph Regional Medical Center, 5215 Holy Cross Parkway, Mishawaka, IN 46545, USAClindamycin is a bacteriostatic lincosamide antibiotic with a broad spectrum. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. The incidence is unknown. It is characterized by increases in aspartate and alanine transaminases. There may be no symptoms and the treatment is to stop the administration of clindamycin. We have described a 62-year-old African American female medicated with acetaminophen and clindamycin who had initially presented to the dental clinic for the evaluation of gum pain following tooth extraction. She had significantly increased levels of liver transaminases, which trended downwards on quitting the medication.http://dx.doi.org/10.1155/2016/2724738 |
| spellingShingle | Jerome Okudo Nwabundo Anusim Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature Case Reports in Hepatology |
| title | Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature |
| title_full | Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature |
| title_fullStr | Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature |
| title_full_unstemmed | Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature |
| title_short | Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature |
| title_sort | hepatotoxicity due to clindamycin in combination with acetaminophen in a 62 year old african american female a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2016/2724738 |
| work_keys_str_mv | AT jeromeokudo hepatotoxicityduetoclindamycinincombinationwithacetaminophenina62yearoldafricanamericanfemaleacasereportandreviewoftheliterature AT nwabundoanusim hepatotoxicityduetoclindamycinincombinationwithacetaminophenina62yearoldafricanamericanfemaleacasereportandreviewoftheliterature |