Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts

Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts

Abstract Interest in understanding the high chemoresistance and poor prognosis of advanced ovarian clear cell carcinoma (OCCC) is rising. Patient-derived xenografts (PDX) are widely used in vivo models because of their supposedly accurate morphologic and (epi)genetic representation of patient tumors...

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Bibliographic Details
Main Authors: Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Ovarian clear cell carcinoma
Patient derived xenografts
ARID1A
Copy number alterations
DNA methylation
Online Access:https://doi.org/10.1038/s41598-025-86384-2
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