The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury
ADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin cytoskeletal architecture and can reduce podocyte migration a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/320531 |
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| author | Beina Teng Alexander Lukasz Mario Schiffer |
| author_facet | Beina Teng Alexander Lukasz Mario Schiffer |
| author_sort | Beina Teng |
| collection | DOAJ |
| description | ADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin cytoskeletal architecture and can reduce podocyte migration and motility. Recent studies suggest that cofilin-1 can be regulated through several extracellular signals and slit diaphragm proteins. Cofilin knockdown and knockout animal models show dysfunction of glomerular barrier and filtration with foot process effacement and loss of secondary foot processes. This indicates that cofilin-1 is necessary for modulating actin dynamics in podocytes. Podocyte alterations in actin architecture may initiate or aid the progression of a large variety of glomerular diseases, and cofilin activity is required for reorganization of an intact filtration barrier. Since almost all proteinuric diseases result from a similar phenotype with effacement of the foot processes, we propose that cofilin-1 is at the centre stage of the development of proteinuria and thus may be an attractive drug target for antiproteinuric treatment strategies. |
| format | Article |
| id | doaj-art-d543079df62b49b3a42f70230482dce9 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-d543079df62b49b3a42f70230482dce92025-02-03T01:30:15ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/320531320531The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte InjuryBeina Teng0Alexander Lukasz1Mario Schiffer2Division of Nephrology, Department of Medicine, Medical School Hannover, 30625 Hannover, GermanyDivision of Nephrology, Department of Medicine, Medical School Hannover, 30625 Hannover, GermanyDivision of Nephrology, Department of Medicine, Medical School Hannover, 30625 Hannover, GermanyADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin cytoskeletal architecture and can reduce podocyte migration and motility. Recent studies suggest that cofilin-1 can be regulated through several extracellular signals and slit diaphragm proteins. Cofilin knockdown and knockout animal models show dysfunction of glomerular barrier and filtration with foot process effacement and loss of secondary foot processes. This indicates that cofilin-1 is necessary for modulating actin dynamics in podocytes. Podocyte alterations in actin architecture may initiate or aid the progression of a large variety of glomerular diseases, and cofilin activity is required for reorganization of an intact filtration barrier. Since almost all proteinuric diseases result from a similar phenotype with effacement of the foot processes, we propose that cofilin-1 is at the centre stage of the development of proteinuria and thus may be an attractive drug target for antiproteinuric treatment strategies.http://dx.doi.org/10.1155/2012/320531 |
| spellingShingle | Beina Teng Alexander Lukasz Mario Schiffer The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury International Journal of Cell Biology |
| title | The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury |
| title_full | The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury |
| title_fullStr | The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury |
| title_full_unstemmed | The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury |
| title_short | The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury |
| title_sort | adf cofilin pathway and actin dynamics in podocyte injury |
| url | http://dx.doi.org/10.1155/2012/320531 |
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