Direct synthesis of mycophenolic acid aryl esters with antioxidant and antiproliferative properties

Direct synthesis of mycophenolic acid aryl esters with antioxidant and antiproliferative properties

Abstract Naturally occurring phenols were incorporated into the mycophenolic acid (MPA) core to form sixteen new MPA derivatives. Ester conjugates of MPA with isoeugenol, methyl o-coumarate, and raspberry ketone exhibited the highest antioxidant activity in the DPPH test. These derivatives were then...

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Main Authors: Juliusz Walczak, Dorota Iwaszkiewicz-Grześ, Magdalena Śliwka-Kaszyńska, Agnieszka Kurdyn, Ewa Augustin, Agnieszka Viapiana, Alina Plenis, Grzegorz Cholewiński
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mycophenolic acid
Natural phenols
Esterification
IMPDH inhibition
Antioxidants
Online Access:https://doi.org/10.1038/s41598-025-11871-5
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https://doi.org/10.1038/s41598-025-11871-5

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