Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study
There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associat...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9294038 |
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| author | Silvio Buscemi Pierfilippo Chiarello Carola Buscemi Davide Corleo Maria Fatima Massenti Anna Maria Barile Giuseppe Rosafio Vincenza Maniaci Valentina Settipani Loretta Cosentino Carla Giordano |
| author_facet | Silvio Buscemi Pierfilippo Chiarello Carola Buscemi Davide Corleo Maria Fatima Massenti Anna Maria Barile Giuseppe Rosafio Vincenza Maniaci Valentina Settipani Loretta Cosentino Carla Giordano |
| author_sort | Silvio Buscemi |
| collection | DOAJ |
| description | There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18–90 years) of the cohort of the ABCD_2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI ≥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if ≥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1%, of whom 27.4% were found to be MH. In addition, 36.7% of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P<0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment. |
| format | Article |
| id | doaj-art-d4f85ec9a11149d4b5351629a8326271 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d4f85ec9a11149d4b5351629a83262712025-02-03T01:22:03ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/92940389294038Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD StudySilvio Buscemi0Pierfilippo Chiarello1Carola Buscemi2Davide Corleo3Maria Fatima Massenti4Anna Maria Barile5Giuseppe Rosafio6Vincenza Maniaci7Valentina Settipani8Loretta Cosentino9Carla Giordano10Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento di Scienze per la Promozione della Salute e Materno Infantile, University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyDipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, ItalyThere is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18–90 years) of the cohort of the ABCD_2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI ≥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if ≥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1%, of whom 27.4% were found to be MH. In addition, 36.7% of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P<0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment.http://dx.doi.org/10.1155/2017/9294038 |
| spellingShingle | Silvio Buscemi Pierfilippo Chiarello Carola Buscemi Davide Corleo Maria Fatima Massenti Anna Maria Barile Giuseppe Rosafio Vincenza Maniaci Valentina Settipani Loretta Cosentino Carla Giordano Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study Journal of Diabetes Research |
| title | Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study |
| title_full | Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study |
| title_fullStr | Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study |
| title_full_unstemmed | Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study |
| title_short | Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study |
| title_sort | characterization of metabolically healthy obese people and metabolically unhealthy normal weight people in a general population cohort of the abcd study |
| url | http://dx.doi.org/10.1155/2017/9294038 |
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