Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel therapeutic avenues

Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel therapeutic avenues

Abstract Background Interleukin 6 receptor (IL6R) inhibitors are effective drugs as therapy for rheumatoid arthritis (RA). However, few studies on IL6R inhibition for relieving chronic low back pain (CLBP) have been conducted. These existing studies are plagued by issues such as small sample sizes a...

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Bibliographic Details
Main Authors: Ding-Qiang Chen, Zhi-Qiang Que, Wen-Bin Xu, Ke-Yi Xiao, Nai-Kun Sun, Jin-Yi Feng, Gang Rui
Format: Article
Language:English
Published: BMC 2025-06-01
Series:European Journal of Medical Research
Subjects:
Chronic low back pain
IL6R
Mendelian randomization
Causality
Online Access:https://doi.org/10.1186/s40001-025-02746-6
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https://doi.org/10.1186/s40001-025-02746-6

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