Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2018/9794625 |
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| author | Ammara Riaz Azhar Rasul Ghulam Hussain Muhammad Kashif Zahoor Farhat Jabeen Zinayyera Subhani Tahira Younis Muhammad Ali Iqra Sarfraz Zeliha Selamoglu |
| author_facet | Ammara Riaz Azhar Rasul Ghulam Hussain Muhammad Kashif Zahoor Farhat Jabeen Zinayyera Subhani Tahira Younis Muhammad Ali Iqra Sarfraz Zeliha Selamoglu |
| author_sort | Ammara Riaz |
| collection | DOAJ |
| description | Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates. |
| format | Article |
| id | doaj-art-d4d2f96c45f54d64a19c9249cca84e67 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-d4d2f96c45f54d64a19c9249cca84e672025-02-03T01:12:24ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422018-01-01201810.1155/2018/97946259794625Astragalin: A Bioactive Phytochemical with Potential Therapeutic ActivitiesAmmara Riaz0Azhar Rasul1Ghulam Hussain2Muhammad Kashif Zahoor3Farhat Jabeen4Zinayyera Subhani5Tahira Younis6Muhammad Ali7Iqra Sarfraz8Zeliha Selamoglu9Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Biochemistry, University of Agriculture, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde 51240, TurkeyNatural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.http://dx.doi.org/10.1155/2018/9794625 |
| spellingShingle | Ammara Riaz Azhar Rasul Ghulam Hussain Muhammad Kashif Zahoor Farhat Jabeen Zinayyera Subhani Tahira Younis Muhammad Ali Iqra Sarfraz Zeliha Selamoglu Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities Advances in Pharmacological Sciences |
| title | Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities |
| title_full | Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities |
| title_fullStr | Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities |
| title_full_unstemmed | Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities |
| title_short | Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities |
| title_sort | astragalin a bioactive phytochemical with potential therapeutic activities |
| url | http://dx.doi.org/10.1155/2018/9794625 |
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