Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking

Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking

Novel 1,3,4-thiadiazole-based pyrazolo[3,4-d]pyrimidine derivatives (7a–7 l) were synthesised in this study, and their structures were ascertained utilizing a range of spectroscopic methods, including HREI-MS, IR, and NMR (1H/13C). They showed especially strong activity (IC50 range 1.56–44 μM). With...

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Bibliographic Details
Main Authors: Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Results in Chemistry
Subjects:
1,3,4-Thiadiazole
Pyrazolo[3,4-d]pyrimidine
Antiproliferative activity
1WCH
2P85
ADME-Tox
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625000761
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