The Skin-Lightening Power of Tirbanibulin 1% Ointment
Abstract Background Tirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AK) on the face and scalp in adults. Recent evidence suggests that, besides the antineoplastic effect, tirbanibulin may also confer substantial cosmetic benefits to patients. Methods We repo...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-11-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-024-01310-0 |
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| author | Federica Li Pomi Andrea d’Aloja Michelangelo Rottura Mario Vaccaro Francesco Borgia |
| author_facet | Federica Li Pomi Andrea d’Aloja Michelangelo Rottura Mario Vaccaro Francesco Borgia |
| author_sort | Federica Li Pomi |
| collection | DOAJ |
| description | Abstract Background Tirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AK) on the face and scalp in adults. Recent evidence suggests that, besides the antineoplastic effect, tirbanibulin may also confer substantial cosmetic benefits to patients. Methods We report a single-center retrospective study of patients affected by solar lentigines (SLs) and AKs in the context of field cancerization treated with tirbanibulin 1% ointment. Results Among 42 patients, 35% (n = 15) experienced complete clearance of SLs, while partial clearance was observed in 50% (n = 21) of patients. Regarding AKs, complete and partial clearance were observed in 52% (n = 22) and 40% (n = 17) of patients, respectively. Major study limitations are the small sample size and the absence of a control group. Conclusions Our results suggest that tirbanibulin 1% ointment may offer the dual benefit of treating AKs while simultaneously lightening aesthetically bothersome and difficult-to-treat lesions like SLs with just 5 days of application. |
| format | Article |
| id | doaj-art-d4b5b9100c614907a611a5c98a0b669e |
| institution | Kabale University |
| issn | 2193-8210 2190-9172 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj-art-d4b5b9100c614907a611a5c98a0b669e2025-02-02T12:09:46ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722024-11-011519511010.1007/s13555-024-01310-0The Skin-Lightening Power of Tirbanibulin 1% OintmentFederica Li Pomi0Andrea d’Aloja1Michelangelo Rottura2Mario Vaccaro3Francesco Borgia4Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of PalermoDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of MessinaDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of MessinaDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of MessinaDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of MessinaAbstract Background Tirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AK) on the face and scalp in adults. Recent evidence suggests that, besides the antineoplastic effect, tirbanibulin may also confer substantial cosmetic benefits to patients. Methods We report a single-center retrospective study of patients affected by solar lentigines (SLs) and AKs in the context of field cancerization treated with tirbanibulin 1% ointment. Results Among 42 patients, 35% (n = 15) experienced complete clearance of SLs, while partial clearance was observed in 50% (n = 21) of patients. Regarding AKs, complete and partial clearance were observed in 52% (n = 22) and 40% (n = 17) of patients, respectively. Major study limitations are the small sample size and the absence of a control group. Conclusions Our results suggest that tirbanibulin 1% ointment may offer the dual benefit of treating AKs while simultaneously lightening aesthetically bothersome and difficult-to-treat lesions like SLs with just 5 days of application.https://doi.org/10.1007/s13555-024-01310-0Actinic keratosisLentiginesSkin agingSolar lentiginesSolar lentigoTirbanibulin |
| spellingShingle | Federica Li Pomi Andrea d’Aloja Michelangelo Rottura Mario Vaccaro Francesco Borgia The Skin-Lightening Power of Tirbanibulin 1% Ointment Dermatology and Therapy Actinic keratosis Lentigines Skin aging Solar lentigines Solar lentigo Tirbanibulin |
| title | The Skin-Lightening Power of Tirbanibulin 1% Ointment |
| title_full | The Skin-Lightening Power of Tirbanibulin 1% Ointment |
| title_fullStr | The Skin-Lightening Power of Tirbanibulin 1% Ointment |
| title_full_unstemmed | The Skin-Lightening Power of Tirbanibulin 1% Ointment |
| title_short | The Skin-Lightening Power of Tirbanibulin 1% Ointment |
| title_sort | skin lightening power of tirbanibulin 1 ointment |
| topic | Actinic keratosis Lentigines Skin aging Solar lentigines Solar lentigo Tirbanibulin |
| url | https://doi.org/10.1007/s13555-024-01310-0 |
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