Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the role of senescence in obesity-induced metabolic disorders and in cardiac dysfunction is not yet clear; therefore, the therapeutic potential of managin...

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Main Authors: Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
Obesity
Cellular senescence
brown adipose tissue
Metabolic dysfunction
Cardiac dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001960
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