APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps.

APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps.

Mice lacking apolipoprotein E (APOE, Apoe-/- mice) on a high cholesterol (HC) diet are highly susceptible to infection with Mycobacterium tuberculosis (Mtb) but the underlying immune dysregulation has been unclear. While neutrophils are often the predominant cell type in the lungs of humans with sev...

Full description

Saved in:
Bibliographic Details
Main Authors: Dong Liu, Dat Mai, Ana N Jahn, Tara A Murray, John D Aitchison, Benjamin H Gern, Kevin B Urdahl, Alan Aderem, Alan H Diercks, Elizabeth S Gold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013267
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.ppat.1013267

Similar Items