Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management

Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management

Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination, neurodegeneration, and inflammation in the central nervous system. The AXL gene, which codes for a receptor tyrosine kinase, has emerged as a promising therapeutic target due to its involvement in neuroinflammati...

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Main Authors: Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Chemistry
Subjects:
AXL gene
antisense oligonucleotides
multiple sclerosis
neurodegeneration inflammation
therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1548269/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1548269/full

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