Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success
Abstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activa...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | The Journal of Headache and Pain |
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| Online Access: | https://doi.org/10.1186/s10194-025-01959-8 |
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| author | Lanfranco Pellesi Lars Edvinsson |
| author_facet | Lanfranco Pellesi Lars Edvinsson |
| author_sort | Lanfranco Pellesi |
| collection | DOAJ |
| description | Abstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this proposal reexamines substance P as a mediator in migraine pathophysiology. Using an established methodological framework, migraine-inducing properties of substance P can be evaluated through randomized, double-blind, placebo-controlled crossover studies involving healthy volunteers and individuals with a history of migraine. This approach aims to establish proof of concept for substance P’s role in migraine, laying the groundwork for investigations with animal and cell-based models and advancing the development of innovative treatments for patients refractory to current therapies. |
| format | Article |
| id | doaj-art-d4678bb2f990420eb0f13d4506caba8e |
| institution | Kabale University |
| issn | 1129-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-d4678bb2f990420eb0f13d4506caba8e2025-02-02T12:34:38ZengBMCThe Journal of Headache and Pain1129-23772025-01-012611410.1186/s10194-025-01959-8Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP successLanfranco Pellesi0Lars Edvinsson1Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern DenmarkDepartment of Medicine, Institute of Clinical Sciences, Lund UniversityAbstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this proposal reexamines substance P as a mediator in migraine pathophysiology. Using an established methodological framework, migraine-inducing properties of substance P can be evaluated through randomized, double-blind, placebo-controlled crossover studies involving healthy volunteers and individuals with a history of migraine. This approach aims to establish proof of concept for substance P’s role in migraine, laying the groundwork for investigations with animal and cell-based models and advancing the development of innovative treatments for patients refractory to current therapies.https://doi.org/10.1186/s10194-025-01959-8CGRPHeadacheSubstance PNeurokininsPain |
| spellingShingle | Lanfranco Pellesi Lars Edvinsson Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success The Journal of Headache and Pain CGRP Headache Substance P Neurokinins Pain |
| title | Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success |
| title_full | Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success |
| title_fullStr | Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success |
| title_full_unstemmed | Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success |
| title_short | Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success |
| title_sort | revisiting substance p in migraine a methodological approach inspired by anti cgrp and anti pacap success |
| topic | CGRP Headache Substance P Neurokinins Pain |
| url | https://doi.org/10.1186/s10194-025-01959-8 |
| work_keys_str_mv | AT lanfrancopellesi revisitingsubstancepinmigraineamethodologicalapproachinspiredbyanticgrpandantipacapsuccess AT larsedvinsson revisitingsubstancepinmigraineamethodologicalapproachinspiredbyanticgrpandantipacapsuccess |