Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study
Background: Patients with type 1 diabetes mellitus have been at heightened risk for developing atrial fibrillation. We aimed to investigate whether this association is causal using Mendelian randomization. Methods: Using publicly available genome-wide association studies data, we selected single nuc...
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Elsevier
2025-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000466 |
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| author | Yongkai Li Shasha Liu Yiming Dong Jianzhong Yang Yingping Tian |
| author_facet | Yongkai Li Shasha Liu Yiming Dong Jianzhong Yang Yingping Tian |
| author_sort | Yongkai Li |
| collection | DOAJ |
| description | Background: Patients with type 1 diabetes mellitus have been at heightened risk for developing atrial fibrillation. We aimed to investigate whether this association is causal using Mendelian randomization. Methods: Using publicly available genome-wide association studies data, we selected single nucleotide polymorphisms significantly associated with type 1 diabetes mellitus as instrumental variables. We employed inverse variance-weighted, weighted median, MR-Egger regression, simple mode, and weighted mode methods within a two-sample Mendelian randomization framework to assess the causal relationship between type 1 diabetes mellitus and atrial fibrillation. We evaluated the pleiotropy and heterogeneity levels of the included genetic instruments using MR-PRESSO, MR-Egger intercept test, Cochran’s Q test, funnel plots, and leave-one-out plots. Results: Causal impact of type 1 diabetes mellitus on atrial fibrillation: Inverse variance weighted (odds ratio [OR] = 0.996, 95 % confidence interval [CI]: 0.985–1.007, P = 0.498). MR-Egger (OR = 1.000, 95 % CI: 0.985–1.016, P = 0.963). Weighted median (OR = 0.985, 95 % CI: 0.973–0.998, P = 0.022). Simple mode (OR = 1.007, 95 % CI: 0.974–1.040, P = 0.698). Weighted mode (OR = 0.995, 95 % CI: 0.984–1.005, P = 0.298). MR-Egger intercept test (P = 0.437). There was no evidence of pleiotropy among the genetic instrumental variables included in the analysis. Conclusions: In Mendelian randomization analysis, we did not find evidence of a causal relationship between genetically determined type 1 diabetes mellitus in European ancestry populations and atrial fibrillation. |
| format | Article |
| id | doaj-art-d44dc24eee4e4bf9bc7c63efc94aa8b0 |
| institution | DOAJ |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-d44dc24eee4e4bf9bc7c63efc94aa8b02025-08-20T02:47:37ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-04-015710164310.1016/j.ijcha.2025.101643Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization studyYongkai Li0Shasha Liu1Yiming Dong2Jianzhong Yang3Yingping Tian4Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaEmergency Department, The Fourth Hospital of Shijiazhuang, Shijiazhuang, ChinaEmergency Department, The Fourth Hospital of Shijiazhuang, Shijiazhuang, ChinaEmergency Trauma Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Corresponding author at: Emergency Trauma Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Corresponding author at: Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.Background: Patients with type 1 diabetes mellitus have been at heightened risk for developing atrial fibrillation. We aimed to investigate whether this association is causal using Mendelian randomization. Methods: Using publicly available genome-wide association studies data, we selected single nucleotide polymorphisms significantly associated with type 1 diabetes mellitus as instrumental variables. We employed inverse variance-weighted, weighted median, MR-Egger regression, simple mode, and weighted mode methods within a two-sample Mendelian randomization framework to assess the causal relationship between type 1 diabetes mellitus and atrial fibrillation. We evaluated the pleiotropy and heterogeneity levels of the included genetic instruments using MR-PRESSO, MR-Egger intercept test, Cochran’s Q test, funnel plots, and leave-one-out plots. Results: Causal impact of type 1 diabetes mellitus on atrial fibrillation: Inverse variance weighted (odds ratio [OR] = 0.996, 95 % confidence interval [CI]: 0.985–1.007, P = 0.498). MR-Egger (OR = 1.000, 95 % CI: 0.985–1.016, P = 0.963). Weighted median (OR = 0.985, 95 % CI: 0.973–0.998, P = 0.022). Simple mode (OR = 1.007, 95 % CI: 0.974–1.040, P = 0.698). Weighted mode (OR = 0.995, 95 % CI: 0.984–1.005, P = 0.298). MR-Egger intercept test (P = 0.437). There was no evidence of pleiotropy among the genetic instrumental variables included in the analysis. Conclusions: In Mendelian randomization analysis, we did not find evidence of a causal relationship between genetically determined type 1 diabetes mellitus in European ancestry populations and atrial fibrillation.http://www.sciencedirect.com/science/article/pii/S2352906725000466Type 1 diabetes mellitusAtrial fibrillationGenome-wide associationMendelian randomization |
| spellingShingle | Yongkai Li Shasha Liu Yiming Dong Jianzhong Yang Yingping Tian Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study International Journal of Cardiology: Heart & Vasculature Type 1 diabetes mellitus Atrial fibrillation Genome-wide association Mendelian randomization |
| title | Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study |
| title_full | Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study |
| title_fullStr | Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study |
| title_full_unstemmed | Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study |
| title_short | Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study |
| title_sort | causal relationship between type i diabetes mellitus and atrial fibrillation a mendelian randomization study |
| topic | Type 1 diabetes mellitus Atrial fibrillation Genome-wide association Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000466 |
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