Mechanisms behind Functional Avidity Maturation in T Cells
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/163453 |
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| _version_ | 1832549960778776576 |
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| author | Marina Rode von Essen Martin Kongsbak Carsten Geisler |
| author_facet | Marina Rode von Essen Martin Kongsbak Carsten Geisler |
| author_sort | Marina Rode von Essen |
| collection | DOAJ |
| description | During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells. |
| format | Article |
| id | doaj-art-d44ad9c48e0f40a990410ca1611abd40 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d44ad9c48e0f40a990410ca1611abd402025-02-03T06:08:11ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/163453163453Mechanisms behind Functional Avidity Maturation in T CellsMarina Rode von Essen0Martin Kongsbak1Carsten Geisler2Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, DenmarkDepartment of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, DenmarkDepartment of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, DenmarkDuring an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.http://dx.doi.org/10.1155/2012/163453 |
| spellingShingle | Marina Rode von Essen Martin Kongsbak Carsten Geisler Mechanisms behind Functional Avidity Maturation in T Cells Clinical and Developmental Immunology |
| title | Mechanisms behind Functional Avidity Maturation in T Cells |
| title_full | Mechanisms behind Functional Avidity Maturation in T Cells |
| title_fullStr | Mechanisms behind Functional Avidity Maturation in T Cells |
| title_full_unstemmed | Mechanisms behind Functional Avidity Maturation in T Cells |
| title_short | Mechanisms behind Functional Avidity Maturation in T Cells |
| title_sort | mechanisms behind functional avidity maturation in t cells |
| url | http://dx.doi.org/10.1155/2012/163453 |
| work_keys_str_mv | AT marinarodevonessen mechanismsbehindfunctionalaviditymaturationintcells AT martinkongsbak mechanismsbehindfunctionalaviditymaturationintcells AT carstengeisler mechanismsbehindfunctionalaviditymaturationintcells |