Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk

Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk

Abstract During the onset and malignant development of liver fibrosis, the pernicious interplay between damaged hepatocytes and activated hepatic stellate cells (HSCs) induce a self‐perpetuating vicious cycle, deteriorating fibrosis progression and posing a grave threat to public health. The secreti...

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Main Authors: Ling‐Feng Zhang, Wen‐Qi Deng, Xing‐Huan Wang, Qing‐Wen Huang, Su‐Qing Liang, Ze‐Quan Ding, Liang Qi, Yi Wang, Tian‐Jiao Zhou, Lei Xing, Jai‐Woo Lee, Yu‐Kyoung Oh, Hu‐Lin Jiang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
cellular crosstalk
chemogene therapy
hepatic stellate cell
hepatocyte
liver fibrosis
Online Access:https://doi.org/10.1002/advs.202408898
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https://doi.org/10.1002/advs.202408898

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