Proteome-wide Mendelian randomization reveals causal associations between plasma proteins and autoimmune thyroid disease

Proteome-wide Mendelian randomization reveals causal associations between plasma proteins and autoimmune thyroid disease

Abstract Autoimmune thyroid diseases (AITD) are the most common autoimmune disorders. Identifying new biomarkers and therapeutic targets in plasma proteins is crucial. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analysis to determine plasma proteins causally associat...

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Bibliographic Details
Main Authors: Yang Li, Weixi Zhu, Yijing Chen, Qingqing Kang, Ying Zhang, Pan Yang, Shumin Wang, Chao Liu, Yi Zhang, Qiu Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Autoimmune thyroid diseases
Plasma protein
Mendelian randomization
Colocalization analysis
Causal association
Online Access:https://doi.org/10.1038/s41598-025-04902-8
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https://doi.org/10.1038/s41598-025-04902-8

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