Targeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors

Targeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors

<b>Background and Objectives</b>: Neuronal nitric oxide synthase (nNOS) overexpressed in melanoma plays a critical role in disease progression. Our previous studies demonstrated that nNOS inhibitors exhibited potent anti-melanoma activity and regulated PD-L1 expressions in the presence o...

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Bibliographic Details
Main Authors: Anika Patel, Shirley Tong, Kate Lozada, Amardeep Awasthi, Richard B. Silverman, Jennifer Totonchy, Sun Yang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
melanoma
interferon-gamma (IFN-γ)
neuronal nitric oxide synthase (nNOS)
nitric oxide (NO)
nNOS inhibitors
programmed death-ligand 1 (PD-L1)
Online Access:https://www.mdpi.com/1999-4923/17/6/691
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