Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis

Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis

Hemophilia A (HA) is associated with FVIII coagulation insufficiency or inactivity leading to excessive bleeding. Elevated FVIII, on the contrary, is associated with thrombophilia, thrombosis, myocardial infarctions, and stroke. Active FVIII (aFVIII) uses its C2 domain to bind to blood cells’ membra...

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Main Authors: Anjud Al-Mohannadi, Reem Mohammed Yahia, Hani Bibawi, Che-Ann Lachica, Watfa Ahmed, Igor Pavlovski, Giusy Gentilcore, Elkhansa Elbukhari Elgaali, Anila Ejaz, Areeg Ahmed, Mohammed Elanbari, Zainab Awada, Mohammed J. Al-Kubaisi, Muhammad Elnaggar, Ayman Saleh, Chiara Cugno, Sara Deola
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
flow cytometry
factor VIII
hemophilia A
leukocytes
monocytes
coagulation
Online Access:https://www.mdpi.com/2073-4409/14/2/73
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