Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation

Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation

Inflammation plays a major role in the development of myocardial ischemia-reperfusion (IR) injury. Recombinant human brain natriuretic peptide (rhBNP), a man-made version of a peptide that is elevated in heart failure, exhibits anti-inflammatory effects in various tissues. However, its role in myoca...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kun-Peng Li, Hai-Yan Zhang, Xiao-Dong Xu, Ming-Yang, Tie-Jun Li, Shu-Tian Song
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Cardiovascular Therapeutics
Online Access:	http://dx.doi.org/10.1155/2020/1389312
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway
by: Zhengguo Qiu, et al.
Published: (2025-02-01)

Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
by: Wang Fang, et al.
Published: (2023-09-01)

Mechanism of mTOR/RILP-regulated autophagic flux in increased susceptibility to myocardial ischemia-reperfusion in diabetic mice
by: Jiyao Zhao, et al.
Published: (2025-01-01)

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism
by: Xinrong Wu, et al.
Published: (2025-01-01)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
by: Juan Du, et al.
Published: (2016-01-01)

L-Borneol 7-O-[β-D-Apiofuranosyl-(1→6)]-β-D-Glucopyranoside Alleviates Myocardial Ischemia-Reperfusion Injury in Rats and Hypoxic/Reoxygenated Injured Myocardial Cells via Regulating the PI3K/AKT/mTOR Signaling Pathway
by: Ziyi Tong, et al.
Published: (2022-01-01)

Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer
by: Athanasia Pavlidou, et al.
Published: (2014-01-01)

Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism
by: Ying-hao Pei, et al.
Published: (2016-01-01)

Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway
by: Jianru Shang, et al.
Published: (2022-01-01)

TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway
by: Lu Shi, et al.
Published: (2019-01-01)

Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase
by: Yinhua Dong, et al.
Published: (2015-01-01)

Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development
by: G. F. Korytina, et al.
Published: (2023-09-01)

Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice
by: Gabriela Xavier Santos, et al.
Published: (2025-01-01)

Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway
by: Jingyan Liu Master degree, et al.
Published: (2021-11-01)

Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway
by: Peng Sun, et al.
Published: (2016-01-01)

Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway
by: Xiaohong Wang, et al.
Published: (2019-01-01)

GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway
by: Chenhua Luo, et al.
Published: (2025-01-01)

The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
by: Elias A. El Habr, et al.
Published: (2012-01-01)

Discussion on the Mechanism of Gandoufumu Decoction Attenuates Liver Damage of Wilson’s Disease by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway Based on Network Pharmacology and Experimental Verification
by: Lulu Tang, et al.
Published: (2023-01-01)

NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target
by: Hongbo Huang, et al.
Published: (2022-01-01)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
by: Chen Wang, et al.
Published: (2022-01-01)

Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway
by: Linhua Lv, et al.
Published: (2022-01-01)

Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway
by: Mingming Xu, et al.
Published: (2025-02-01)

Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress
by: Jinjie Li, et al.
Published: (2019-01-01)

Erratum to “Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway”
by: Yi Yang, et al.
Published: (2021-01-01)

β-glucan attenuates intestinal ischemia-reperfusion injury in mice by promoting glucagon-like peptide-1 secretion
by: WANG Wei, et al.
Published: (2025-01-01)

Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway.
by: Li Li, et al.
Published: (2025-01-01)

Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice
by: Qiuhua Zhou, et al.
Published: (2025-02-01)

Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway
by: Attalla Farag El-kott, et al.
Published: (2019-01-01)

Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)
by: Fateme Arjmand, et al.
Published: (2024-07-01)

N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy
by: Sheng Wang, et al.
Published: (2017-01-01)

Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway
by: Fei Zhang, et al.
Published: (2025-03-01)

Metformin Facilitates Osteoblastic Differentiation and M2 Macrophage Polarization by PI3K/AKT/mTOR Pathway in Human Umbilical Cord Mesenchymal Stem Cells
by: Min Shen, et al.
Published: (2022-01-01)

Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway
by: Teng Sun, et al.
Published: (2025-01-01)

Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway
by: Yanni Pan, et al.
Published: (2025-01-01)

Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
by: Gao Y, et al.
Published: (2025-01-01)

APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K/AKT/mTOR pathway
by: Jing Gao, et al.
Published: (2025-01-01)

Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo
by: Meng Minjun, et al.
Published: (2023-03-01)

Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson’s Disease
by: Kawinthra Khwanraj, et al.
Published: (2016-01-01)

Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling
by: Yasuhiro Izumiya, et al.
Published: (2012-01-01)