Discovery of broadly neutralizing VHHs against short-chain α-neurotoxins using a consensus toxin as an antigen

Discovery of broadly neutralizing VHHs against short-chain α-neurotoxins using a consensus toxin as an antigen

Snakebite envenoming is a neglected tropical disease that afflicts millions of people globally, leading to substantial morbidity and mortality. Developing novel antivenoms, particularly recombinant antivenoms based on broadly neutralizing monoclonal antibodies, offers a promising strategy to address...

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Bibliographic Details
Main Authors: Anna Damsbo, Melisa Benard-Valle, Tom Jansen, Nick J. Burlet, Max D. Overath, Alid Guadarrama-Martínez, Kim Boddum, Alejandro Alagon, Esperanza Rivera-de-Torre, Andreas H. Laustsen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Antibody discovery
broadly neutralizing antibodies
consensus toxins
nanobodies
neurotoxins
phage display technology
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2522838
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2522838

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