Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal
Abstract While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behav...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56023-5 |
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| _version_ | 1832585597009526784 |
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| author | Diego E. Hernandez Andrei Ciuparu Pedro Garcia da Silva Cristina M. Velasquez Benjamin Rebouillat Michael D. Gross Martin B. Davis Honggoo Chae Raul C. Muresan Dinu F. Albeanu |
| author_facet | Diego E. Hernandez Andrei Ciuparu Pedro Garcia da Silva Cristina M. Velasquez Benjamin Rebouillat Michael D. Gross Martin B. Davis Honggoo Chae Raul C. Muresan Dinu F. Albeanu |
| author_sort | Diego E. Hernandez |
| collection | DOAJ |
| description | Abstract While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. Responses to the same sensory cue are strongly modulated upon changes in stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton responses occurs within seconds of the rule-reversal events and is correlated with changes in behavior. Optogenetic perturbation of cortical feedback within the bulb disrupts the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback axons carry stimulus identity and reward contingency signals which are rapidly re-formatted according to changes in the behavioral context. |
| format | Article |
| id | doaj-art-d3ce9ddffc4f4a989d5c94ee456a8ce7 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d3ce9ddffc4f4a989d5c94ee456a8ce72025-01-26T12:42:08ZengNature PortfolioNature Communications2041-17232025-01-0116112010.1038/s41467-025-56023-5Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversalDiego E. Hernandez0Andrei Ciuparu1Pedro Garcia da Silva2Cristina M. Velasquez3Benjamin Rebouillat4Michael D. Gross5Martin B. Davis6Honggoo Chae7Raul C. Muresan8Dinu F. Albeanu9Cold Spring Harbor LaboratoryTransylvanian Institute of NeuroscienceCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryTransylvanian Institute of NeuroscienceCold Spring Harbor LaboratoryAbstract While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. Responses to the same sensory cue are strongly modulated upon changes in stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton responses occurs within seconds of the rule-reversal events and is correlated with changes in behavior. Optogenetic perturbation of cortical feedback within the bulb disrupts the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback axons carry stimulus identity and reward contingency signals which are rapidly re-formatted according to changes in the behavioral context.https://doi.org/10.1038/s41467-025-56023-5 |
| spellingShingle | Diego E. Hernandez Andrei Ciuparu Pedro Garcia da Silva Cristina M. Velasquez Benjamin Rebouillat Michael D. Gross Martin B. Davis Honggoo Chae Raul C. Muresan Dinu F. Albeanu Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal Nature Communications |
| title | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_full | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_fullStr | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_full_unstemmed | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_short | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_sort | fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule reversal |
| url | https://doi.org/10.1038/s41467-025-56023-5 |
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