Evolution and maintenance of a large multidrug-resistant plasmid in a Salmonella enterica Typhimurium host under differing antibiotic selection pressures

Evolution and maintenance of a large multidrug-resistant plasmid in a Salmonella enterica Typhimurium host under differing antibiotic selection pressures

ABSTRACT The dissemination of antibiotic resistance genes (ARGs) through plasmids is a major mechanism for the development of bacterial antimicrobial resistance. The adaptation and evolution mechanisms of multidrug-resistant (MDR) plasmids with their hosts are not fully understood. Herein, we conduc...

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Main Authors: Ming Cheng, Jing-Jing Dai, Jin-Fei Zhang, Yu-Ting Su, Si-Qi Guo, Ruan-Yang Sun, Dong Wang, Jian Sun, Xiao-Ping Liao, Sheng Chen, Liang-Xing Fang
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mSystems
Subjects:
plasmid
fitness cost
antibiotic resistance
experimental evolution
positive selection
loss of plasmid-encoded ARGs
Online Access:https://journals.asm.org/doi/10.1128/msystems.01197-24
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https://journals.asm.org/doi/10.1128/msystems.01197-24

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