Acetylation of α-tubulin restores endothelial cell injury and blood–brain barrier disruption after intracerebral hemorrhage in mice

Acetylation of α-tubulin restores endothelial cell injury and blood–brain barrier disruption after intracerebral hemorrhage in mice

Abstract Damage to endothelial cells (ECs) is a key factor in blood–brain barrier (BBB) disruption after intracerebral hemorrhage (ICH). While microtubules are essential for EC structure, their role in BBB injury remains unclear. Here we investigated the role of acetylated α-tubulin (α-Ac-Tub) in BB...

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Main Authors: Xuejiao Lei, Eryi Sun, Xufang Ru, Yulian Quan, Xuezhu Chen, Qian Zhang, Yougling Lu, Qianying Huang, Yujie Chen, Wenyan Li, Hua Feng, Yang Yang, Rong Hu
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01454-9
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https://doi.org/10.1038/s12276-025-01454-9

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