Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2018/1585749 |
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| author | M. S. Sobolev A. V. Faitelson O. S. Gudyrev D. S. R. Rajkumar G. M. Dubrovin A. V. Anikanov N. U. Koklina E. S. Chernomortseva |
| author_facet | M. S. Sobolev A. V. Faitelson O. S. Gudyrev D. S. R. Rajkumar G. M. Dubrovin A. V. Anikanov N. U. Koklina E. S. Chernomortseva |
| author_sort | M. S. Sobolev |
| collection | DOAJ |
| description | The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them. |
| format | Article |
| id | doaj-art-d35c1c308a874172a27a73a176ed94a4 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-d35c1c308a874172a27a73a176ed94a42025-02-03T01:24:20ZengWileyJournal of Osteoporosis2090-80592042-00642018-01-01201810.1155/2018/15857491585749Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in ExperimentM. S. Sobolev0A. V. Faitelson1O. S. Gudyrev2D. S. R. Rajkumar3G. M. Dubrovin4A. V. Anikanov5N. U. Koklina6E. S. Chernomortseva7Kursk Regional Children’s Hospital No-2, No-43a, Khutorskaya Street, Kursk, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaDepartment of Pharmacology, Belgorod State National Research University, 85 Pobedy Street, Belgorod, 308015, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaDepartment of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, RussiaThe experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them.http://dx.doi.org/10.1155/2018/1585749 |
| spellingShingle | M. S. Sobolev A. V. Faitelson O. S. Gudyrev D. S. R. Rajkumar G. M. Dubrovin A. V. Anikanov N. U. Koklina E. S. Chernomortseva Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment Journal of Osteoporosis |
| title | Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment |
| title_full | Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment |
| title_fullStr | Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment |
| title_full_unstemmed | Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment |
| title_short | Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment |
| title_sort | study of endothelio and osteoprotective effects of combination of rosuvastatin with l norvaline in experiment |
| url | http://dx.doi.org/10.1155/2018/1585749 |
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