Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, w...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/940210 |
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| _version_ | 1832556300091785216 |
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| author | Oya Cingöz John M. Coffin |
| author_facet | Oya Cingöz John M. Coffin |
| author_sort | Oya Cingöz |
| collection | DOAJ |
| description | Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples. |
| format | Article |
| id | doaj-art-d3508357faf74a65a2e81b6faa3ee655 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-d3508357faf74a65a2e81b6faa3ee6552025-02-03T05:45:51ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/940210940210Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA SamplesOya Cingöz0John M. Coffin1Department of Molecular Biology and Microbiology and Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USADepartment of Molecular Biology and Microbiology and Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USAXenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples.http://dx.doi.org/10.1155/2011/940210 |
| spellingShingle | Oya Cingöz John M. Coffin Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples Advances in Virology |
| title | Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples |
| title_full | Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples |
| title_fullStr | Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples |
| title_full_unstemmed | Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples |
| title_short | Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples |
| title_sort | endogenous murine leukemia viruses relationship to xmrv and related sequences detected in human dna samples |
| url | http://dx.doi.org/10.1155/2011/940210 |
| work_keys_str_mv | AT oyacingoz endogenousmurineleukemiavirusesrelationshiptoxmrvandrelatedsequencesdetectedinhumandnasamples AT johnmcoffin endogenousmurineleukemiavirusesrelationshiptoxmrvandrelatedsequencesdetectedinhumandnasamples |