A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells

A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells

Summary: Polycomb repressive complex 2 (PRC2), composed of the core subunits EED, SUZ12, and either EZH1 or EZH2, is critical for maintaining cellular identity in multicellular organisms. PRC2 deposits H3K27me3, which is thought to recruit the canonical form of PRC1 (cPRC1) to promote gene repressio...

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Main Authors: Rachel McCole, James Nolan, David M. Reck, Craig Monger, Samantha Rustichelli, Eric Conway, Gerard L. Brien, Cheng Wang, Orla Deevy, Hannah K. Neikes, Frances M. Bashore, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Sarena F. Flanigan, Diego Pasini, Chen Davidovich, Michiel Vermeulen, Lindsey I. James, Evan Healy, Adrian P. Bracken
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724015432
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