Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Abstract Bone loss and microstructural destruction in elderly men are associated with fractures and high mortality. While testosterone (Tes) is considered to be possibly protective, its regulatory mechanism in bone remodeling remains unclear. Here, bone microarchitectural analysis indicates that eld...

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Bibliographic Details
Main Authors: Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
bone destruction
male bones
osteoblastic androgen receptor
tenascin‐C
Online Access:https://doi.org/10.1002/advs.202501518
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https://doi.org/10.1002/advs.202501518

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