Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes
Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classif...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-025-00719-w |
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| author | Fresia Pareja Rohit Bhargava Virginia F. Borges Edi Brogi Rita Canas Marques Fatima Cardoso Christine Desmedt Malini Harigopal Sunil R. Lakhani Adrian Lee Jose Pablo Leone Hannah Linden Christopher J. Lord Caterina Marchio Sofia D. Merajver Emad Rakha Jorge S. Reis-Filho Andrea Richardson Elinor Sawyer Pepper Schedin Christopher J. Schwartz Andrew Tutt Naoto T. Ueno Anne Vincent-Salomon Britta Weigelt Y. Hannah Wen Stuart J. Schnitt Steffi Oesterreich |
| author_facet | Fresia Pareja Rohit Bhargava Virginia F. Borges Edi Brogi Rita Canas Marques Fatima Cardoso Christine Desmedt Malini Harigopal Sunil R. Lakhani Adrian Lee Jose Pablo Leone Hannah Linden Christopher J. Lord Caterina Marchio Sofia D. Merajver Emad Rakha Jorge S. Reis-Filho Andrea Richardson Elinor Sawyer Pepper Schedin Christopher J. Schwartz Andrew Tutt Naoto T. Ueno Anne Vincent-Salomon Britta Weigelt Y. Hannah Wen Stuart J. Schnitt Steffi Oesterreich |
| author_sort | Fresia Pareja |
| collection | DOAJ |
| description | Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored. |
| format | Article |
| id | doaj-art-d344112a69f74f31a661e3aa38ba0c64 |
| institution | Kabale University |
| issn | 2374-4677 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj-art-d344112a69f74f31a661e3aa38ba0c642025-01-26T12:45:47ZengNature Portfolionpj Breast Cancer2374-46772025-01-0111111310.1038/s41523-025-00719-wUnraveling complexity and leveraging opportunities in uncommon breast cancer subtypesFresia Pareja0Rohit Bhargava1Virginia F. Borges2Edi Brogi3Rita Canas Marques4Fatima Cardoso5Christine Desmedt6Malini Harigopal7Sunil R. Lakhani8Adrian Lee9Jose Pablo Leone10Hannah Linden11Christopher J. Lord12Caterina Marchio13Sofia D. Merajver14Emad Rakha15Jorge S. Reis-Filho16Andrea Richardson17Elinor Sawyer18Pepper Schedin19Christopher J. Schwartz20Andrew Tutt21Naoto T. Ueno22Anne Vincent-Salomon23Britta Weigelt24Y. Hannah Wen25Stuart J. Schnitt26Steffi Oesterreich27Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens HospitalDivision of Medical Oncology, University of Colorado Anschutz Medical CampusDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Champalimaud FoundationBreast Unit, Champalimaud Clinical Centre/Champalimaud FoundationLaboratory for Translational Breast Cancer Research, Department of Oncology, KU LeuvenDepartment of Pathology, Icahn School of Medicine at Mount SinaiUQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, and Pathology QueenslandWomen’s Cancer Research Center, Magee-Womens Research Institute, UPMC Hillmann Cancer CenterDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDivision of Hematology and Oncology, Fred Hutchinson Cancer Center/University of WashingtonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchCandiolo Cancer Institute, FPO - IRCCS, CandioloBreast and Ovarian Cancer Risk Evaluation Program, Department of Internal Medicine, Michigan MedicineDepartment of Pathology, School of Medicine, University of Nottingham and Nottingham University Hospitals NHS TrustDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, John Hopkins MedicineSchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, Guy’s Cancer Centre, King’s College LondonKnight Cancer Institute, Oregon Health & Science UniversityDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchBreast Medical Oncology, University of Hawaii Cancer CenterDepartment of Pathology, Curie Institute, Paris Sciences Lettres UniversityDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Brigham and Women’s HospitalWomen’s Cancer Research Center, Magee-Womens Research Institute, UPMC Hillmann Cancer CenterAbstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.https://doi.org/10.1038/s41523-025-00719-w |
| spellingShingle | Fresia Pareja Rohit Bhargava Virginia F. Borges Edi Brogi Rita Canas Marques Fatima Cardoso Christine Desmedt Malini Harigopal Sunil R. Lakhani Adrian Lee Jose Pablo Leone Hannah Linden Christopher J. Lord Caterina Marchio Sofia D. Merajver Emad Rakha Jorge S. Reis-Filho Andrea Richardson Elinor Sawyer Pepper Schedin Christopher J. Schwartz Andrew Tutt Naoto T. Ueno Anne Vincent-Salomon Britta Weigelt Y. Hannah Wen Stuart J. Schnitt Steffi Oesterreich Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes npj Breast Cancer |
| title | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| title_full | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| title_fullStr | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| title_full_unstemmed | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| title_short | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| title_sort | unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| url | https://doi.org/10.1038/s41523-025-00719-w |
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