Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome
The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and i...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/276079 |
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| _version_ | 1832559863610212352 |
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| author | Lisa Wenyang Fu Ronald Vender |
| author_facet | Lisa Wenyang Fu Ronald Vender |
| author_sort | Lisa Wenyang Fu |
| collection | DOAJ |
| description | The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway. There is an increased prevalence of metabolic syndrome in patients with psoriasis. Metabolic syndrome also involves a proinflammatory state. This paper proposes the idea of the potential use of oral vitamin D to treat psoriasis and metabolic syndrome concurrently. We propose there is merit in more clinical trials investigating the use of vitamin D to treat both psoriasis and metabolic syndrome through its anti-inflammatory effects. On application to psoriasis management and prognosis, the goal is to decrease the risk for cardiovascular disease and decrease disease morbidity and mortality. |
| format | Article |
| id | doaj-art-d320f29a12b94173a2d2f8fa59526d65 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-d320f29a12b94173a2d2f8fa59526d652025-02-03T01:29:09ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/276079276079Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic SyndromeLisa Wenyang Fu0Ronald Vender1Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5, CanadaDepartment of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5, CanadaThe novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway. There is an increased prevalence of metabolic syndrome in patients with psoriasis. Metabolic syndrome also involves a proinflammatory state. This paper proposes the idea of the potential use of oral vitamin D to treat psoriasis and metabolic syndrome concurrently. We propose there is merit in more clinical trials investigating the use of vitamin D to treat both psoriasis and metabolic syndrome through its anti-inflammatory effects. On application to psoriasis management and prognosis, the goal is to decrease the risk for cardiovascular disease and decrease disease morbidity and mortality.http://dx.doi.org/10.1155/2011/276079 |
| spellingShingle | Lisa Wenyang Fu Ronald Vender Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome Dermatology Research and Practice |
| title | Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome |
| title_full | Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome |
| title_fullStr | Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome |
| title_full_unstemmed | Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome |
| title_short | Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome |
| title_sort | systemic role for vitamin d in the treatment of psoriasis and metabolic syndrome |
| url | http://dx.doi.org/10.1155/2011/276079 |
| work_keys_str_mv | AT lisawenyangfu systemicroleforvitamindinthetreatmentofpsoriasisandmetabolicsyndrome AT ronaldvender systemicroleforvitamindinthetreatmentofpsoriasisandmetabolicsyndrome |