Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice

Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive loss of motor neurons, with genetic and environmental factors contributing to its complex pathogenesis. Dysregulated immune responses and altered energetic metabolism are key fea...

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Main Authors: Elena Niccolai, Leandro Di Gloria, Maria Chiara Trolese, Paola Fabbrizio, Simone Baldi, Giulia Nannini, Cassandra Margotta, Claudia Nastasi, Matteo Ramazzotti, Gianluca Bartolucci, Caterina Bendotti, Giovanni Nardo, Amedeo Amedei
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Genetic background
SOD1
Immune response
Microbiome
MCFA
Online Access:https://doi.org/10.1186/s40478-024-01877-x
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https://doi.org/10.1186/s40478-024-01877-x

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