The change of long tail fibers expanded the host range of a T5-like Salmonella phage and its application in milk

The change of long tail fibers expanded the host range of a T5-like Salmonella phage and its application in milk

Abstract We engineered novel T5-like bacteriophage (phage) with extended host ranges by editing the long-tail fibers (PB3 and PB4) to combat Salmonella Enteritidis. By replacing the long-tail fibers PB3 and PB4 regions of phage PH204 with those from phage SP76, we created phages RPA1 − 3 and RPB1 − ...

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Bibliographic Details
Main Authors: Xiaofeng Zheng, Xin Wang, Pei Li, Yu Zhou, Xihui Zhu, Zimeng Hu, Hui Wang, Mianmian Chen, Xiang Huo, Yingyu Liu, Wei Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Microbiology
Subjects:
Salmonella
Homologous recombination
T5-like phages
Host range expansion
Online Access:https://doi.org/10.1186/s12866-025-03895-8
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https://doi.org/10.1186/s12866-025-03895-8

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