Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model

Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model

Type 2 diabetes (T2D) and obesity strongly lead to diabetic cardiomyopathy (DCM). The involvement of mitochondria-associated reticular membranes (MAMs), a signaling hub in the cardiomyocyte, starts to be demonstrated in T2D-related metabolic disorders. We recently discovered a cardiac MAM Ca2+ uncou...

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Main Authors: Hala Guedouari, Maya Dia, Juliette Geoffray, Camille Brun, Florentin Moulin, Lucas Givre, Lucid Belmudes, Christelle Leon, Stephanie Chanon, Jingwei Ji-Cao, Christophe Chouabe, Sylvie Ducreux, Claire Crola Da Silva, Ludovic Gomez, Yohann Couté, Helene Thibault, Jennifer Rieusset, Melanie Paillard
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
SR-mitochondria coupling
MERCs
Database
Diabetic cardiopathy
Mitochondrial calcium uniporter
ERMCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125001722
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