Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells
The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. The cell cycle plays a crucial role in regulating the evolution of radio- and chemo-resistance in tumor cells. Cancer stem cells (CSCs) are the primary source of therapy resistance, with CD133 being one of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1509675/full |
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| author | Luyao Wu Luyao Wu Takanori Katsube Xiaofei Li Bing Wang Yi Xie |
| author_facet | Luyao Wu Luyao Wu Takanori Katsube Xiaofei Li Bing Wang Yi Xie |
| author_sort | Luyao Wu |
| collection | DOAJ |
| description | The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. The cell cycle plays a crucial role in regulating the evolution of radio- and chemo-resistance in tumor cells. Cancer stem cells (CSCs) are the primary source of therapy resistance, with CD133 being one of the most recognized and valuable cell surface markers of CSCs. Evidence increasingly suggests that CD133 is associated with cancer resistance. The current understanding of the molecular biological function of CD133 is limited, leading to ongoing debates about its role in cancer biology. In this review, we explore recent research and emerging trends related to CD133 through extensive literature and content analysis. It was summarized that new insights into the relationships of CD133 and cell cycle signaling pathways in resistant CSCs. The aim of this review is to provide a foundational understanding of how these signaling pathways and their interactions impact cancer prognosis and inform treatment strategies. |
| format | Article |
| id | doaj-art-d2be8092dca0458cab0401d5f262b539 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-d2be8092dca0458cab0401d5f262b5392025-02-06T05:21:40ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-02-011310.3389/fpubh.2025.15096751509675Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cellsLuyao Wu0Luyao Wu1Takanori Katsube2Xiaofei Li3Bing Wang4Yi Xie5Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaGraduate School of the Chinese Academy of Sciences, Beijing, ChinaInstitute for Radiological Science, National Institutes for Quantum Science and Technology, Chiba, JapanGansu Nuclear and Radiation Safety Center, Lanzhou, ChinaInstitute for Radiological Science, National Institutes for Quantum Science and Technology, Chiba, JapanInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaThe adaptation of malignancy to therapy presents a significant challenge in cancer treatment. The cell cycle plays a crucial role in regulating the evolution of radio- and chemo-resistance in tumor cells. Cancer stem cells (CSCs) are the primary source of therapy resistance, with CD133 being one of the most recognized and valuable cell surface markers of CSCs. Evidence increasingly suggests that CD133 is associated with cancer resistance. The current understanding of the molecular biological function of CD133 is limited, leading to ongoing debates about its role in cancer biology. In this review, we explore recent research and emerging trends related to CD133 through extensive literature and content analysis. It was summarized that new insights into the relationships of CD133 and cell cycle signaling pathways in resistant CSCs. The aim of this review is to provide a foundational understanding of how these signaling pathways and their interactions impact cancer prognosis and inform treatment strategies.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1509675/fullmalignancycancer stem cellsCD133radio- and chemo-resistancecell cycle |
| spellingShingle | Luyao Wu Luyao Wu Takanori Katsube Xiaofei Li Bing Wang Yi Xie Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells Frontiers in Public Health malignancy cancer stem cells CD133 radio- and chemo-resistance cell cycle |
| title | Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells |
| title_full | Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells |
| title_fullStr | Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells |
| title_full_unstemmed | Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells |
| title_short | Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells |
| title_sort | unveiling the impact of cd133 on cell cycle regulation in radio and chemo resistance of cancer stem cells |
| topic | malignancy cancer stem cells CD133 radio- and chemo-resistance cell cycle |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1509675/full |
| work_keys_str_mv | AT luyaowu unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells AT luyaowu unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells AT takanorikatsube unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells AT xiaofeili unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells AT bingwang unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells AT yixie unveilingtheimpactofcd133oncellcycleregulationinradioandchemoresistanceofcancerstemcells |