Sphingolipid metabolism-related genes for the diagnosis of metabolic syndrome by integrated bioinformatics analysis and Mendelian randomization identification

Sphingolipid metabolism-related genes for the diagnosis of metabolic syndrome by integrated bioinformatics analysis and Mendelian randomization identification

Abstract Background The rising global incidence of metabolic syndrome (MetS) highlights the need for more effective diagnostic and therapeutic tools. Sphingolipid metabolites are crucial in MetS pathogenesis, and identifying related biomarkers could improve treatment strategies. Methods Differential...

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Main Authors: Weidong Li, Qixing Zhong, Naisheng Deng, Xinhao Zhou, Haitao Wang, Jun Ouyang, Zhifen Guan, Bohao Cheng, Lijun Xiang, Yueming Huang, Yao Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Metabolic syndrome
Sphingolipid metabolism
PTPN18 and TAX1BP3
Mendelian randomization
Key module genes
Online Access:https://doi.org/10.1186/s13098-025-01803-8
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