Transplant of Induced Pluripotent Stem Cell–Derived Retinal Pigment Epithelium Strips for Macular Degeneration and Retinitis Pigmentosa

Transplant of Induced Pluripotent Stem Cell–Derived Retinal Pigment Epithelium Strips for Macular Degeneration and Retinitis Pigmentosa

Purpose: To explore the safety and efficacy of the allogeneic induced pluripotent stem cell (iPSC)–derived retinal pigment epithelium (RPE) strip transplantation for patients with RPE degeneration. Design: Single-arm, open-label, interventional study. Participants: Three eyes from 3 patients clinica...

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Main Authors: Daiki Sakai, MD, Michiko Mandai, MD, PhD, Yasuhiko Hirami, MD, PhD, Midori Yamamoto, BA, Shin-ichiro Ito, MD, PhD, Saori Igarashi, MD, Satoshi Yokota, MD, PhD, Hirofumi Uyama, MD, PhD, Masashi Fujihara, MD, PhD, Akiko Maeda, MD, PhD, Motoki Terada, BS, Mitsuhiro Nishida, MS, Yumiko Shibata, MS, Naoko Hayashi, MS, Kyoko Iseki, MA, Takuya Miura, MS, Keisuke Kajita, MD, PhD, Masaaki Ishida, MD, PhD, Sunao Sugita, MD, PhD, Tadao Maeda, MD, PhD, Masayo Takahashi, MD, PhD, Yasuo Kurimoto, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ophthalmology Science
Subjects:
Age-related macular degeneration
iPS cells
Retinal pigment epithelium
Retinitis pigmentosa
RPE transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914525000685
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