The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.

The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.

Rift Valley fever virus (RVFV) is an encephalitic bunyavirus that can infect neurons in the brain. There are no approved therapeutics that can protect from RVFV encephalitis. Innate immunity, the first line of defense against infection, canonically antagonizes viruses through interferon signaling. W...

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Main Authors: Trevor Griesman, Cynthia M McMillen, Seble Getenet Negatu, Jesse J Hulahan, Kanupriya Whig, Lenka Dohnalová, Mark Dittmar, Christoph A Thaiss, Kellie A Jurado, David C Schultz, Amy L Hartman, Sara Cherry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-06-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012343&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012343&type=printable

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