Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy
Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2...
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| Format: | Article |
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Sociedade Brasileira de Nefrologia
2025-01-01
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| Series: | Brazilian Journal of Nephrology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000101001&lng=en&tlng=en |
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| author | Thaíza Passaglia Bernardes Thalita Alvarenga Ferradosa Paula Gabriel Teixeira Montezuma Sales Patrícia Varela Calais Renato Demarchi Foresto Luiz Antonio Moura Marcelino de Souza Durão Junior João Bosco Pesquero Gianna Mastroianni Kirsztajn |
| author_facet | Thaíza Passaglia Bernardes Thalita Alvarenga Ferradosa Paula Gabriel Teixeira Montezuma Sales Patrícia Varela Calais Renato Demarchi Foresto Luiz Antonio Moura Marcelino de Souza Durão Junior João Bosco Pesquero Gianna Mastroianni Kirsztajn |
| author_sort | Thaíza Passaglia Bernardes |
| collection | DOAJ |
| description | Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, and severe acute kidney injury were noted. SLE was diagnosed and parvovirus B19 DNA was detected in serum samples. Kidney biopsy showed CG without any typical features of lupus nephritis. The patient was treated with prednisone and presented marked improvement of anemia and kidney function after a few weeks. In this case, the patient with SLE presented CG possibly caused by parvovirus B19 infection associated with homozygous apolipoprotein 1 (APOL1) G1 genotype, which has been described as a determinant risk factor for this glomerulopathy. It is not clear whether SLE had a causal relationship with glomerular disease or was a concurrent cause. Treatment can be challenging in such a context, as no antiviral drug is efficient and immunosuppression has no discernable benefit, although steroid use was efficient in treating renal manifestations in this case. |
| format | Article |
| id | doaj-art-d21aa366d80a407da7a7ef39b2a05964 |
| institution | Kabale University |
| issn | 2175-8239 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-d21aa366d80a407da7a7ef39b2a059642025-01-21T07:35:21ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392025-01-0147110.1590/2175-8239-jbn-2024-0104enCollapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathyThaíza Passaglia Bernardeshttps://orcid.org/0000-0003-4877-0859Thalita Alvarenga Ferradosa Paulahttps://orcid.org/0000-0002-8623-1883Gabriel Teixeira Montezuma Saleshttps://orcid.org/0000-0002-7618-2782Patrícia Varela Calaishttps://orcid.org/0000-0002-2165-0761Renato Demarchi Forestohttps://orcid.org/0000-0001-9370-0265Luiz Antonio Mourahttps://orcid.org/0009-0003-8647-1363Marcelino de Souza Durão Juniorhttps://orcid.org/0000-0003-1341-5697João Bosco Pesquerohttps://orcid.org/0000-0002-4507-632XGianna Mastroianni Kirsztajnhttps://orcid.org/0000-0003-1317-4109Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, and severe acute kidney injury were noted. SLE was diagnosed and parvovirus B19 DNA was detected in serum samples. Kidney biopsy showed CG without any typical features of lupus nephritis. The patient was treated with prednisone and presented marked improvement of anemia and kidney function after a few weeks. In this case, the patient with SLE presented CG possibly caused by parvovirus B19 infection associated with homozygous apolipoprotein 1 (APOL1) G1 genotype, which has been described as a determinant risk factor for this glomerulopathy. It is not clear whether SLE had a causal relationship with glomerular disease or was a concurrent cause. Treatment can be challenging in such a context, as no antiviral drug is efficient and immunosuppression has no discernable benefit, although steroid use was efficient in treating renal manifestations in this case.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000101001&lng=en&tlng=enCollapsing GlomerulopathyParvovirus B19Systemic Lupus ErythematosusAPOL1Nephropathy |
| spellingShingle | Thaíza Passaglia Bernardes Thalita Alvarenga Ferradosa Paula Gabriel Teixeira Montezuma Sales Patrícia Varela Calais Renato Demarchi Foresto Luiz Antonio Moura Marcelino de Souza Durão Junior João Bosco Pesquero Gianna Mastroianni Kirsztajn Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy Brazilian Journal of Nephrology Collapsing Glomerulopathy Parvovirus B19 Systemic Lupus Erythematosus APOL1 Nephropathy |
| title | Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy |
| title_full | Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy |
| title_fullStr | Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy |
| title_full_unstemmed | Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy |
| title_short | Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy |
| title_sort | collapsing glomerulopathy associated with parvovirus b19 and systemic lupus erythematosus in a patient with apol1 high risk variant for nephropathy |
| topic | Collapsing Glomerulopathy Parvovirus B19 Systemic Lupus Erythematosus APOL1 Nephropathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000101001&lng=en&tlng=en |
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